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It is important to note that, per protocol, dose escalation stopped when a patients major motor seizure frequency was reduced by 50% of baseline. The mean age of participants was 11.4 years ( 4.4) and they had failed a median of five antiepileptic therapies (range:3-7) prior to this study. At study initiation, patients were receiving a median of four antiepileptic therapies. The median number of major motor seizures (defined as generalized tonic-clonic, tonic, atonic, and focal seizures with a motor component) during the four-week baseline period was 60 (range 21-1360). In the Intent-to-Treat (ITT) patient population (n=13), there was a median 50% reduction in seizure frequency over the entire treatment period compared to baseline (range: +74% to 90%), with seven patients (54%) to date achieving a 50% reduction (range: 50% to 90%) in the number of major motor seizures in this step dose study. There were no cardiovascular-related adverse events observed. The most common treatment-related adverse events were decreased appetite (n=3), decreased alertness/fatigue (n=3) and insomnia (n=2). Three patients withdrew due to adverse events (decreased alertness (n=2) and insomnia (n=1) and one patient withdrew due to lack of effect (the patient was initially a responder, but lost response after undergoing surgery during the trial). These initial results for ZX008 in LGS are quite compelling for this refractory group of patients, said Professor Lagae. A significant unmet medical need currently exists in the treatment of LGS and these initial data indicate that ZX008 has the potential to be a safe and effective adjunctive treatment for this rare pediatric epilepsy condition. I look forward to continuing to evaluate ZX008 in this ongoing Phase 2 open-label study. The Dravet syndrome data highlighted updated results from the ongoing prospective study in Belgium with the new patient cohort (n=9). All of these patients began add-on treatment with low-dose fenfluramine (5 mg to 20 mg per day) at various starting points between 2010 and January 2016. the job interviewMedian treatment duration was 2.1 years (range 0.8 to 5.6 years). During the 90-day run-in period prior to initiating low-dose fenfluramine treatment, the median frequency of major motor seizures (defined as tonic, clonic, tonic-clonic, atonic, and myoclonic seizures lasting >30 seconds) was 15.0 per month (range 0.4 to 39.7).
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